시스테아민은 인체 조직에 생물학적으로 존재합니다
- 인간 세포에서 생리적으로 생성되는 가장 단순한 아미노티올입니다
- 모유에서 고농도의 시스테아민이 발견됩니다
- 생체 적합성 및 내약성
Science Behind
50년 동안 입증된 시스테아민 효능
시스테아민은 피부에 강력한 항산화 작용을 제공합니다
- 티로시나아제 억제
- 퍼옥시다아제 억제
- 세포 내 글루타치온 증가
- 다크 멜라닌 감소
Considerable efficacy
Hsu et al (2013) Journal of the American Accademy of Dermatology 68 (4,1) AB189, P6024
Significant efficacy both by investigators’ and patients’ assessment
Mansouri et al (2015) British Journal of Dermatology 173 (1) 209-217
Higher pigment correction compared to all other agents
Kasraee (2017) 23rd International Pigment Cell Conference in Denver Co, USA
Superior benefit / risk ratio compared to all other agents
Goorochurn (2017) 26th Meeting of the EADV, Geneva, Switzerland
Significant efficacy in pigment correction
Farshi et al (2018) Journal of Dermatological Treatment, 29 (2) 182-189
Isobionic-Amide a new lightening agent technology
- Isobionic-Amide is a part of the vitamin B3 family, which are naturally occurring molecules.
- Isobionic-Amide has a pyridine structure in para-isomer configuration.
- Isobionic-Amide related INCI function is skin conditioning. It is as well use pharmacologically to increase the bioavailability of other molecules by formation of co-crystals
Increased potency
- Scientis discovered in 2011 the depigmenting effect of Isobionic-Amide
- The effectiveness of Isobionic Amide was first hypothesized by analysing the chemical isomer configuration of the pyridine family in comparison of the biphenol family
- Similarly to hydroquinone vs. resorcinol, the hypothesis was that a pyridine in para configuration would be more potent than in Meta configuration
- In-vitro evaluation confirmed the greater potency of Isobionic-Amide vs. niacinamide
- Scientis patented in 2013 the synergy between Cysteamine and Isobionic-Amide
Excellent safety profile
- Considered as hydrophilic with a partition coefficient: Log P= -0.282, which is favorable to penetrate through corneal layer.
- Considered low molecular weight at 122,125 g/mol, which is favorable to diffuse in epidermis.
- Considered readily biodegradable
- Negligeable Acute Toxicity
– LD50 (oral, rat) is > 2.000 mg/kg
– No death observed at oral dose of
>875 mg/kg in rat3 - Not considered teratogenic & mutagenic
- Low Melanocytes & Keratinocytes cytotoxicity
– None up to very high concentration (500µM), as for
Niacinamide.4,5
– Considerably less toxic to melanocytes compared to
other depigmenting agents (25µM for hydroquinone and
hydroquinone-acetate7 ; 100µM for kojic acid and arbutin8) - Non-Carcinogenic
– Not carcinogenic at 5g/kg bw/day (mice, 1% solutions in
drinking water during their lifetime, equivalent to 5g/kg bw/day)
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