Cysteamine 50 years of proven efficacy

Cysteamine is biologically present in human tissue

  • The simplest aminothiol physiologically produced in human cells
  • A high concentration of cysteamine is found in human milk
  • Biocompatible and well tolerated

Cysteamine delivers powerful antioxidant activity in the skin

  • Inhibition of tyrosinase
  • Inhibition of peroxidase
  • Increase of intra-cellular glutathione
  • Reduction of dark melanin

Considerable efficacy

Hsu et al (2013) Journal of the American Accademy of Dermatology 68 (4,1) AB189, P6024

Significant efficacy both by investigators’ and patients’ assessment

Mansouri et al (2015) British Journal of Dermatology 173 (1) 209-217

Higher pigment correction compared to all other agents

Kasraee (2017) 23rd International Pigment Cell Conference in Denver Co, USA

Superior benefit / risk ratio compared to all other agents

Goorochurn (2017) 26th Meeting of the EADV, Geneva, Switzerland

Significant efficacy in pigment correction

Farshi et al (2018) Journal of Dermatological Treatment, 29 (2) 182-189

Isobionic-Amide a new lightening agent technology

  • Isobionic-Amide is a part of the vitamin B3 family, which are naturally occurring molecules.
  • Isobionic-Amide has a pyridine structure in para-isomer configuration.
  • Isobionic-Amide related INCI function is skin conditioning. It is as well use pharmacologically to increase the bioavailability of other molecules by formation of co-crystals

Increased potency

  • Scientis discovered in 2011 the depigmenting effect of Isobionic-Amide
  • The effectiveness of Isobionic Amide was first hypothesized by analysing the chemical isomer configuration of the pyridine family in comparison of the biphenol family
  • Similarly to hydroquinone vs. resorcinol, the hypothesis was that a pyridine in para configuration would be more potent than in Meta configuration
  • In-vitro evaluation confirmed the greater potency of Isobionic-Amide vs. niacinamide
  • Scientis patented in 2013 the synergy between Cysteamine and Isobionic-Amide

Excellent safety profile

  • Considered as hydrophilic with a partition coefficient: Log P= -0.282, which is favorable to penetrate through corneal layer.
  • Considered low molecular weight at 122,125 g/mol, which is favorable to diffuse in epidermis.
  • Considered readily biodegradable
  • Negligeable Acute Toxicity
    – LD50 (oral, rat) is > 2.000 mg/kg
    – No death observed at oral dose of
    >875 mg/kg in rat3
  • Not considered teratogenic & mutagenic

  • Low Melanocytes & Keratinocytes cytotoxicity
    – None up to very high concentration (500µM), as for
    – Considerably less toxic to melanocytes compared to
    other depigmenting agents (25µM for hydroquinone and
    hydroquinone-acetate7 ; 100µM for kojic acid and arbutin8)
  • Non-Carcinogenic
    – Not carcinogenic at 5g/kg bw/day (mice, 1% solutions in
    drinking water during their lifetime, equivalent to 5g/kg bw/day)

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